snps

SSNRI AND SNP REACTIONS CONT

QUESTION: I have a 42yo female patient with anxiety/depression and lots of COMT/MAO SNPs. She recently was put on Cymbalta and it is working really well. This surprised me because I would expect a norepinephrine re-uptake inhibitor to potentially exacerbate her anxiety if she has more trouble metabolizing catecholamines. Can you shed any light on …

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GENOMIC SNP TESTING ACCURACY CONT

QUESTION: Any thoughts on this piece of research, forwarded to me from a patient noting a 40% inaccuracies in SNP assessments? That would be quite high based on the changes we might recommend to patients based on the reported SNPs. “According to information derived from the GAOs report on Consumer Genetic Testing, a SNP analysis …

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ELEVATED COBALAMIN CONT

QUESTION: 49 year old F diagnosed a few years ago with Peripheral Spondyloarthritis. She is currently taking Naproxen 220mg BID, Sulfasalazine 2500mg QD, Fexofenadine 60mg, CoQ10 100mg, B12/folate 1000mcg/800mcg, Milk Thistle, Turmeric, Vitamin D, Probiotic, MSM, and Ligatone. Her PCP found that she was anemic (RBC: 3.94, Hgb: 11.9, Hct: 34.9%, and WBC: 4.6). I …

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MTHFR AND EPIGENETICS CONT

QUESTION: Why should I even care about MTHFR and Epigenetics? ANSWER: MTHFR mutations ‘may’ be more of an issue in modern times due to a few factors: we know they exist now and can test for them most ‘folate’ supplementation in the past was with less or inactive forms most research on ‘folate’ was looking …

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THERAPY FOR METHYLATION SNPS, GLUCURONIDATION AND SULFATION REACTION SUPPORT CONT

QUESTION: I am following up on our discussion about your treatment protocol for patients that have severe methylation issues, and your slow titrations/nutritional protocols. I discussed with you a patient with COMT homozygous, MTHFR heterozygous, and GST allele absent, who has numerous multi-system complaints and has a pacemaker. He tried only 2 grams of MSM …

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IV NUTRIENT REACTIONS CONT

QUESTION: I had a female patient with an interesting case of side effects with vitamins and minerals IV. After the IV, patient experienced mood swings, crying, feeling hungover and disoriented for next 3 days. Patient tolerated IV well except transient nausea resolved with protein snack during the IV. Do you ever see this kind of reaction …

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HISTAMINE REACTIONS AND SNPS CONT

QUESTION: A: A 35 yo female patient of mine is having really weird reactions to foods. She is on an SCD/low histamine diet and avoiding IgG food reactions. Still, 1-2x/week she is experiencing what she refers to as “throat closing” or throat tightness within 10-15mins of eating. The food triggers are random and inconsistent. The …

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BIOFILM TREATMENT CONT

QUESTION: My concern is throwing anything new into the mix to treat possible biofilms. I worry GI support, herbs, and medications will trigger a worsening of the patient’s symptoms, namely angioedema. Do I stabilize the histamine breakdown first before going after the GI system? ANSWER: In my experience most all aggravate (in this patient type …

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GENETIC TESTING CONT.

MY QUESTIONS ARE: 23 and me versus other genetic testing ANSWER: RE: 23 and Me: Nothing is changed, you always had to go outside for  real SNP assessment and you still do (23 and me just has to do less of the “you have a 23% chance of cancer”…) but after they have the raw …

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AUTOIMMUNITY Cont.

MY QUESTIONS ARE: What is a way to attempt to think globally about autoimmunity so I can consider as many potential causes when beginning a diagnostic and therapeutic approach? ANSWERS: Autoimmune cause areas to consider – Multiple cause areas can be considered and identified – Generally in most autoimmunity there are multisystem considerations Follow therapy, …

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ADHD MEDICATION EFFECTS

ADHD MEDICATION EFFECTS CONT

QUESTION: 11 year old girl with ADHD on Vyvanse and Trazadone. Major concern is sleep onset insomnia (despite the meds) and mood swings. We have done IgG testing and they are following her diet, as well as Dr Alan Gaby’s ADHD protocol (Mg, B6, omega’s, etc).If her insomnia and mood swings are a side effect …

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