methylation

BURNING PAIN WITH METHYL FOLATE CONT

QUESTION: I have a patient with C677T homozygous, symptoms started after a dose (literally one dose) of Cipro (previously tolerated) in 2008. Can tolerate methyl cobalamin but methyl folate brings on intolerable burning in arms and legs, which stops when she stops the MTHF. She had this symptom originally (along with tendon tears and other …

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THERAPY FOR METHYLATION SNPS, GLUCURONIDATION AND SULFATION REACTION SUPPORT CONT

QUESTION: I am following up on our discussion about your treatment protocol for patients that have severe methylation issues, and your slow titrations/nutritional protocols. I discussed with you a patient with COMT homozygous, MTHFR heterozygous, and GST allele absent, who has numerous multi-system complaints and has a pacemaker. He tried only 2 grams of MSM …

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HISTAMINE REACTIONS AND SNPS CONT

QUESTION: A: A 35 yo female patient of mine is having really weird reactions to foods. She is on an SCD/low histamine diet and avoiding IgG food reactions. Still, 1-2x/week she is experiencing what she refers to as “throat closing” or throat tightness within 10-15mins of eating. The food triggers are random and inconsistent. The …

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MTHFR and EBV-HHV flares

Most have seen this: Warning: Improving your methylation may trigger an EBV relapse This article points to the idea of “correcting methylation causes EBV relapse”. In one sense, true BUT: without working genomics and especially methylation one becomes (much more likely to be) a chronic re-activator of EBV and other HHV Viri. We saw this association …

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GST DEFECT SUPPORT CONT

QUESTION: As you are the SNP/Methylation man – I’m wondering if you have any resources on GSTT1 deletion and how to support a healthy 30y/o female looking for preventative care. I understand that this gene is responsible for binding environmental toxins to glutathione so that it can be neutralized. I’m not sure that giving support, …

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AUTOIMMUNITY Cont.

MY QUESTIONS ARE: What is a way to attempt to think globally about autoimmunity so I can consider as many potential causes when beginning a diagnostic and therapeutic approach? ANSWERS: Autoimmune cause areas to consider – Multiple cause areas can be considered and identified – Generally in most autoimmunity there are multisystem considerations Follow therapy, …

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