Glutathione

Separating Intravenous Ascorbic Acid [IV Ascorbate] and Glutathione on the same Day in Oxidative Therapies. Rationale and limitations of clinical timing.

Dr. Paul S. Anderson While non-oxidant doses of intravenous vitamin c (IVC) and glutathione (GSH) are synergistic in support of the ReDox cascade between physiological compartments (Cytosol-Cell Membrane-Plasma-Plasma Lipids)* it was previously theorized that an oxidant therapy such as high dose IVC (HDIVC) may be defeated by addition of GSH in proximity. Chen et. al …

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Myelodysplasia: Potential Therapies

Dr. Paul S. Anderson Based on known data regarding MDS and its etiology as well as potential therapies (see below) there is a low probability of ‘cure’ using known therapies.  Supportive care is the mainstay of therapy especially in patients over 60 years of age. Oxidative treatments are indicated, as well as transplantation, growth factors, …

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Vitamin A Accutane Toxicity Notes

VITAMIN A and ACCUTANE TOXICITY NOTES

Dr. PAUL S. ANDERSON METABOLISM – ELIMINATION:   Vitamin A: Cytochrome p450, and especially CYP3A4 oxidizing excess retinol, Vitamin D intake (a known CYP3A4-inducer), iron intake (CYP3A4 has an iron center), Copper and vitamin C.  Accutane (13-cisRA) cytochrome P450 enzymes (CYPs) including 2C8, 3A7, 4A11, 1B1, 2B6 and 2C9 responsible for the generation of 13-cisRA …

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Sulfur Dioxide VOG Considerations

Sulfur dioxide is water soluble and an immediate stress on the respiratory apparatus, and then the cardiovascular and neurological systems to name a few. It is primary detoxified via SUOX which can be slow for three reasons: SUOX SNPs, heavy metal effect such as tungsten and cofactor insufficiency (molybdenum). Of note this detox pathway is …

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Close up of an IV Drip

IV Glutathione in epileptic patients

Is it safe to administer IV glutathione in an epileptic patient on keppra and with cerebral palsy? And… Have you administered IV glutathione in patients with g6pd deficiency given the redox cycle in red blood cells? Dr. Anderson: Clinically I have seen no problem with epileptics, Keppra and GSH, same with G6PD deficiency (actually is …

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Glutathione and epilepsy medication

Clinical Case Questions: IVs Administered: Is it safe to administer IV glutathione in a patient with cerebral palsy, on epileptic medication – with no seizures for the last 5 years? She has pretty severe psoriasis as well…hoping that something like glutathione IV is beneficial. Thanks for your teaching and help! Dr. Anderson: Generally very safe. …

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TRAUMATIC BRAIN INJURY AND INTEGRATIVE MEDICINE IN PRACTICE

BLOG AND LITERATURE REVIEW REFERENCE: Understanding the neuroinflammatory response following concussion to develop treatment strategies. Neuroinflammation is becoming more and more associated in the literature with a host of downstream comorbidities including depression, anxiety, addictive behavior, dementia and others. Concussion and the traumatic brain injury that follows can be devastating to the health and long …

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PEDIATRIC AML IV IDEAS CONT

QUESTION: The case is more tricky just because of the little girl’s age. At 9 months of age she was diagnosed with AML subtype M7. Chemo was started right away and at the time my role was to support chemotherapy with homeopathy and treat the mother with supplementation as she is actively nursing. She made …

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POST STROKE THERAPY CONT

QUESTION: 51 year old female patient, with malignant hypertensive heart disease (yrs of being un medicated, she is an athlete, free diver etc), ischemic stroke 2 months ago, some hemiplegia and hemiparesis, post-stroke meds: carvedilol, lisinopril, simvastatin, losartan, aspirin. Very healthy otherwise, BP managed well now. Are there any contraindications to IV therapy with glutathione …

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MTHFR IN INFANTS CONT

QUESTION: Do you have experience in treating gene defect in infants? 7 month old homozygous for either A677T or A1298CC (mother couldn’t remember, but the child was tested). Normal growth and development, but after last vaccine (dtap) she got tremors 25 hours later that resolved over 2 weeks. Mother has homozygous MTHFR defect that created …

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THERAPY FOR METHYLATION SNPS, GLUCURONIDATION AND SULFATION REACTION SUPPORT CONT

QUESTION: I am following up on our discussion about your treatment protocol for patients that have severe methylation issues, and your slow titrations/nutritional protocols. I discussed with you a patient with COMT homozygous, MTHFR heterozygous, and GST allele absent, who has numerous multi-system complaints and has a pacemaker. He tried only 2 grams of MSM …

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IV THERAPY POST MI CONT

QUESTION: I have a patient with prostate cancer and a rising PSA after prostatectomy. He’s coming off a lupron shot, which is when the PSA started increasing. I treated him with basic naturopathic care with attention to the cancer, including 50 g AA twice weekly for a month. He has now had a massive heart …

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HISTAMINE REACTIONS AND SNPS CONT

QUESTION: A: A 35 yo female patient of mine is having really weird reactions to foods. She is on an SCD/low histamine diet and avoiding IgG food reactions. Still, 1-2x/week she is experiencing what she refers to as “throat closing” or throat tightness within 10-15mins of eating. The food triggers are random and inconsistent. The …

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