QUESTION: Do you have experience in treating gene defect in infants? 7 month old homozygous for either A677T or A1298CC (mother couldn’t remember, but the child was tested). Normal growth and development, but after last vaccine (dtap) she got tremors 25 hours later that resolved over 2 weeks. Mother has homozygous MTHFR defect that created fertility issues. Mother is doing delayed vaccination schedule and was considering starting with a basic kids multi with folate and adding from there. She is scheduled for her next round of vaccines in 9 months. I will be seeing her for the initial visit soon. Baby is nursing.
ANSWER: I normally try to supplement through mom if nursing. A well rounded B-Complex with active forms on top of a multi are best (since you don’t know all the SNP’s mom and baby have.) A B-Complex with at least 700-1200mcg 5MTHF or Calcium Folinate (if mom doesn’t tolerate methylators – i.e.agitation) and 500-1000 mcg Methyl or other more active (non cyano) B-12. Assure it has minimum 25-35 mg P5P as well. Also Trace elements and Magnesium are vital co-factors for the B-Vits so they need to be supplemented (look at the Prenatal mom is taking first). Finally mom (and baby) need glutathione support to balance it all, typically this is plenty to support all concerned, if not I have done the above in baby doses in food or bottle direct to baby. And – of course – counsel re high active folate foods!