P-5-P REACTIONS CONT

Reactions that seem paradoxical to P5P can be from a plethora of genesis.

Most common are:

  1. Increase CBS and thus increase sulfite load (and if SUOX has been slow this can act like migraine, mania or insomnia) — this also can alter glutathione metabolism creating more “agitation” symptoms. —
  2. Increase TRYP & 5HTP conversion to Serotonin and increase the Melatonin substrate pool leading to either somnolence or agitation —
  3. Increase activity of AST and AALT suddenly relating to “active” liver symptoms —
  4. Also can suddenly cause shift in glutamate/histamine and other neurotransmitter metabolism.

* Most is transient but still may last 2-3 weeks

** If magnesium is not being supplemented enough (it is the main ionic co-factor for B6) then the reactions can be partially from that

*** If Mag is being supplemented then often the fault is in deficient Taurine (which allows magnesium and other minerals to equilibrate at cell membrane sites.

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