Biology of Muscle and Therapies Suggested
The researchers found four main differences in cultured skeletal muscle cells from subjects with CFS; increased myogenin expression in the basal state, impaired activation of AMPK, impaired stimulation of glucose uptake and diminished release of IL6. The retention of these differences in cultured muscle cells from CFS subjects points to a genetic/epigenetic mechanism, and provides potential to identify novel therapeutic targets.
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CFS FMS chronic fatigue muscle pain myalgia AMPK chronic illness Brown AE, Jones DE, Walker M, Newton JL. (2015) Abnormalities of AMPK Activation and Glucose Uptake in Cultured Skeletal Muscle Cells from Individuals with Chronic Fatigue Syndrome.