QUESTION:
32 YO F W/ CC OF DRY, BURNING LIPS
Patient is homozygous for MTHFR 677. Has been worked up by myself and multiple other practitioners, including neurology, and nothing abnormal in serum except positive IgG for HHV6 and Mycoplasma.
The only thing that has ever helped her is SAMe. She’s experienced a significant but incomplete reduction in symptoms. Allergies are present but no sign of autoimmune or other neurological involvement.
PEA, NE and DA are elevated on NT panel. Will be repeating that, considering a methylation panel later.
I am very curious about the connection between SAMe and what I am calling this unusual paresthesia-type symptom. Any thoughts on the cause would be appreciated. Thank you very much in advance!!!
ANSWER:
These neuro – paresthesia cases are, in my experience, the worst to track down a cause for. Likely as they involve many causes that (if not collaboratively acted on) wind up aggravating each other.
SAMe helps a few people so the fact is does is notable. It can be the methyl donation, the catecholamine support or a few other things. Use it as long as it works but there has to be more support needed…
I’d really get an entire genomic panel done looking at the whole methyl cycle and especially look at SHMT and BHMT as they can ‘switch’ things so methylation Rx are not enough.
I’d also look at the catecholamine production and degradation on the panel and then Phase-2 issues (these three areas are a start). 23 and me with a Sterlings app would get this for you.
I’d also do some kind of a GI test for bugs and make sure the noted infectious disease things get treated as they will leave background cytokines that aggravate already existing neural issues.