This webcall will focus differently from the prior one on histamine in June, as it concentrates on peripheral histamine metabolism in atopy, allergy and like conditions. We review HIS in the CNS, including neurotransmitter balance and metabolism then move to catecholamine metabolism, methylation and interactions with glutamate and NMDA receptors. We talk about global gut-brain inflammation syndrome and different prescriptions that effect histamine and H1 vs H2 receptors. Membrane phospholipids, immune stimuli, cytokine reactions and mast cell activation are discussed followed by mastocytosis, the role of GSH and Redox. Atopic pathology and primary support therapies with nutrient dosing strategies over time and a conversation about the order of addition and other clinical parameters.